Abstract:

The solubility and stability of active pharmaceutical ingredients (APIs) in solid-state formulations play a crucial role in drug development and formulation design. Coformers, which are typically crystalline materials that interact with APIs through non-covalent interactions, have gained significant attention as potential additives to enhance the solubility and stability of APIs. This research paper presents a systematic study on the optimization of API to coformer ratios to achieve enhanced solubility and stability in pharmaceutical formulations. The study employs a combination of experimental techniques, computational modeling, and characterization methods to elucidate the underlying mechanisms governing the API-coformer interactions

Description:

Active Pharmaceutical Ingredient (API), Coformer, Cocrystal, Solubility, Stability, Formulation Design, Computational Modeling