Abstract:

To facilitate access to a wide variety of pharmaceutically interesting and diversely functionalized compounds, a water-mediated and catalyst-free simple approach has been developed. 5-Alkyl- 10-aryl or heteroaryl-2,8-dioxo or dithioxo-9,10-dihydropyrido[2,3-d:6,5-d']isoquinoline.analogs of 1,3,5,7-tetrahydrodipyrimidine-4,6-dione 5,5'-(1,4-phenylene)bis(10-alkyl/aryl-2,8- dioxo/dithio-9,10-dihydropyrido[2,3-d:6,5-d']quinoxaline) and 4 (4-1-4-42)The one-pot multicomponent reaction of barbituric/N,N-dimethyl barbituric/thiobarbituric acids (1), substituted amines (2), and aldehydes (3) at room temperature led to the development of dipyrimidine-4,6(1H,3H,5H,7H)-dione) 4′ (4′-1-4′-8). High atom-economy and low E-factor, good to excellent yields, reusability of reaction media, and a clean reaction profile are just some of the highlights of this protocol. Water is used as the reaction media, and the reaction takes place at room temperature under mild conditions

Description:

Bioactive, Pharmaceutically, Antibacterial, Pyrimidine, Synthesis