Abstract:

The reaction of acetophenone with substituted aldehydes is a suitable strategy for the synthesis of numerous benzothiazepine derivatives. The acetophenone scaffold is the foundation of the benzothiazepine scaffold. However, aldehydes that have been "substituted" allow for the introduction of new functional groups and substituents, allowing the pharmacological profile to be fine-tuned. The significance of this study is driven by the current dearth of effective and selective anticonvulsant medicines. Producing and screening a library of 1,5-benzothiazepine derivatives to examine the structure-activity relationship (SAR) can lead to the discovery of compounds with improved anticonvulsant effect. The insights gathered from this study into the mechanisms of action of these compounds will help in the development of more effective anticonvulsant drugs. The simplicity and effectiveness of the synthetic approach make it possible to synthesize on a large scale, which will be essential for future preclinical and clinical studies. The ability to synthesis these compounds in sufficient numbers enables thorough in vitro and in vivo studies, including pharmacokinetic and toxicological research, expanding our understanding of their potential as anticonvulsant medicines.

Description:

benzothiazepine derivatives, acetophenone scaffold, pharmacological profile, anticonvulsant medicines, 1,5-benzothiazepine derivatives